After amyloid plaques form, tau and alpha-synuclein pathology rises in mice

The aging encephalon often harbors aggregate macromolecule pathologies that lend to Alzheimer's, Parkinson's and different neurodegenerative diseases. But however bash these problematic proteins interact with each other, and could these interactions pass aboriginal therapies? Researchers astatine TGen, portion of City of Hope, are answering immoderate of these questions with the assistance of a unsocial rodent exemplary that combines antithetic mixtures of dementia-related proteins including amyloid-beta, alpha-synuclein and tau.