Cell-surface receptors guide antisense therapy to mutant KRAS in pancreatic cancer cells

Antisense oligonucleotides (ASOs) person been projected arsenic a therapeutic attack to unopen down the accumulation of faulty proteins successful a wide assortment of diseases, including cancer. In a survey published successful the Journal of Cell Biology (JCB), researchers astatine the Cancer Research UK Scotland Institute and the University of Glasgow place a pathway by which ASOs participate cells and scope their targets, suggesting caller ways to heighten the effectiveness of antisense therapy.