Economic evaluation supports prophylactic naldemedine for opioid-induced constipation in cancer palliative care

Although opioids stay indispensable for symptom alleviation successful patients with precocious cancer, their usage often results successful OIC, which tin substantially trim prime of beingness and, successful immoderate cases, compromise the continuation of optimal symptom management. Naldemedine, a peripherally acting μ-opioid receptor antagonist, is utilized to dainty OIC by preserving physiological bowel motility without interfering with cardinal analgesia.