Polyubiquitin may stabilize tau filament structures in neurodegenerative diseases

In neurodegenerative diseases specified arsenic Alzheimer's disease, progressive neuronal harm is associated with the accumulation of abnormal tau filaments successful the brain. The halfway of these filaments forms a highly ordered structure, portion molecules specified arsenic ubiquitin are attached to tau astir the halfway arsenic post-translational modifications. However, the relation these peripheral modifications play successful maintaining the structural stableness of tau filaments remains unclear.